CAS： 38304-91-5, Minoxidil

Basic information

cas: 38304-91-5

English name: minoxidil

English alias: Regaine; Theroxidil; Minoximen; 2, 4 diamino - 6 - piperidino - pyrimidine - 3 - oxide; 3-hydroxy-2-imino-6-piperidin-1-ylpyrimidin-4-amine; 6-(1-Piperidinyl)-2, 4-Pyrimidinediamine 3-oxide; 6-(1-Piperidinyl) Pyrimidine2,4-diamine 3-oxide; Rogaine; Alostil; 2, 6-diamino-4 -(piperidin-1-yl)pyrimidine 1-oxide; Loniten; 6-(1-Piperidinyl)-2, 4-Pyrimidinediamine 3-oxide; 6-(1-Piperidinyl) Pyrimidine2,4-diamine 3-oxide; Lonolox; 2, 6-diamino-4-piperidinopyrimidine 1-Oxide; Minoxidil; Tricoxidil;

Molecular formula: C9H15N5O

Molecular weight: 209.24800

Accurate mass: 209.12800

PSA: 91.16000

LOGP: 0.91830

Physicochemical property

Appearance and properties: white crystalline powder

Density: 1.52g /cm3

Boiling point: 351.7ºC at 760 mmHg

Melting point: 272-274 °C (dec.)(lit.)

Flash point: 166.5ºC

Refractive index: 1.724

Stability: Stable at normal temperatures and pressures.

Keep in a cool, dry location. Keep containers closed when not in use. Protect from light. Keep in a cool, dry location. Keep containers closed when not in use. Protect from light.

Safety information

RTECS number: UV8200000

Safety Description: S26-S36

Danger class code: R22; R36/37/38

WGK Germany: 3

Customs Code: 2933990090

Dangerous Goods Mark: Xn

Production method and application

Production method

4-chloro-2, 6-diaminopyrimidine (see 08910) was obtained from methyl cyanoacetate by cyclization and chlorination. It was then oxidized with perbenzoic acid to obtain 6-amino-1, 2-dihydro-1-hydroxy-2-imino-4-chloropyrimidine (C4H5CIN4O), and finally condensed with hexahydropyridine to produce minolidine.

use

Hypotensive drug for refractory, primary or renal hypertension. Used to prevent oil alopecia and animal husbandry.

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